Colistin 3 MIU Injection

Colistin 3 MIU Injection is a polymyxin antibiotic containing Colistimethate Sodium used to treat serious infections caused by multidrug-resistant Gram-negative bacteria. It is often used as a last resort when other antibiotics have failed and this is usually in a hospital.

Uses of Colistin 3 MIU Injection:

Severe Bacterial Infections

How does Colistin 3 MIU Injection work?

Colistin sodium is an inactive prodrug which is converted to the active form in the body after administration. Colistin has a bactericidal activity through binding to phospholipids and lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria. This binding causes cell death by disrupting the cell membrane, increasing its permeability and releasing the cellular contents.

How to Use & Dosage?

Usually given as an intravenous infusion. The dose depends on the severity of the infection, the patient’s weight and renal function. Healthcare practitioners should monitor it closely for adjustment based on the risk of toxicity and the therapeutic response.

Colistimethate injections are usually given by injection into a muscle or as a mixture of powder and liquid injected into a vein over a period of 3 to 5 minutes, every 6 to 12 hours.

How long will you need to take therapy? This will depend on your health, type of illness and how well you respond to the drug. Also can be administered as continuous infusion of 22–23 hours.

Continue to use the colistimethate injection even if you feel better until you have completed the full prescribed amount. If you stop the colistimethate injection too early or miss doses, your infection may not be completely treated and bacteria may become resistant to antibiotics.

Possible Side Effects:

• Dizziness
• Tingling
• Muscle weakness
• Nausea
• Vomiting
• Skin Rash
• Itching
• Diarrhea
• Kidney Damage

Safety Advise:

Lungs

It is not known whether Colistin Injection can be used safely in people who have lung problems. Please speak with your healthcare provider.

Liver

Colistin Injection is not safe for people with certain problems. Please consult with your healthcare provider.

Kidney

Colistin Injection may cause kidney problems. It is not known if Colistin Injection is safe and effective in patients with kidney problems. Please talk to your health care provider.

Pregnancy

During pregnancy, colistin should be used only if clearly needed. Please discuss with your healthcare provider.

Breastfeeding

Using Colistin while nursing is most likely dangerous. Please talk to your health care provider.

Storage Instructions:

Store vials at 2°C to 8°C. Store in the original container, protected from light. Do not freeze.

References:

1. Celebi S, Hacimustafaoglu M, Koksal N, Ozkan H, Çetinkaya M. Colistimethate sodium therapy for multidrug‐resistant isolates in pediatric patients. Pediatrics International. 2010 Jun;52(3):410-4.
2. Athanassa ZE, Markantonis SL, Fousteri MZ, Myrianthefs PM, Boutzouka EG, Tsakris A, Baltopoulos GJ. Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients. Intensive care medicine. 2012 Nov;38:1779-86.
3. Koerner-Rettberg C, Ballmann M. Colistimethate sodium for the treatment of chronic pulmonary infection in cystic fibrosis: an evidence-based review of its place in therapy. Core evidence. 2014 Sep 9:99-112.

Disclaimer:

IHS Enterprises’s primary objective is to guarantee the accuracy, reliability, and specialist review of the information it provides to customers. The contents and information provided on this website are for informational purposes only. They should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician for guidance and any questions you may have about any condition or medication. If you do read anything from IHS Enterprises, please do not discount or delay in seeking competent medical advice. We want to enhance the doctor-patient relationship, not substitute it.

Manufacturer details:

Name: Taj Pharma India Ltd
Address: 1st floor, 15-6-108 afzal gunj, hyderabad, telangana 500012
Country of origin: India

Frequently Asked Questions (FAQs):

1. What is Colistin 3 MIU Injection?

Colistin 3 MIU contains Colistimethate sodium, a polymyxin antibiotic. It is prescribed for severe, life-threatening infections caused by multi-drug resistant bacteria, under strict hospital supervision.

2. How does Colistin work?

It is thought to work as a detergent on the cell membranes of Gram-negative bacteria . This may result in the death of bacterial cells and elimination of the infection .

3. When could it be considered?

It is prescribed for severe pneumonia, bacteremia or complicated urinary tract infections caused by resistant pathogens under doctor’s evaluation.

4. How is it given?

It is given IV (intravenous infusion) and sometimes by inhalation. You are to adhere strictly to the clinical administration protocols of your medical team.

5. How do you decide on the dose?

The dosage is highly individual and depends solely on the body weight of the patient, renal function and the severity of the infection. This can only be calculated by a doctor.

6. What side effects may occur?

In patients, dizziness, numbness or tingling (neurotoxicity) or reactions at the injection site may occur. Report these to nursing staff immediately.

7. What are the serious kidney risks?

Yes it is deemed very nephrotoxic. During therapy, doctors will need to monitor kidney function daily, with strict adherence, to possibly prevent severe renal damage.

8. Does it cause breathing difficulties?

It may cause neurotoxicity resulting in muscle weakness or respiratory depression. Medical staff will observe you closely and you must follow all safety checks.

9. How compatible is it with other antibiotics?

Yes, it can be used in combination with other antibiotics. The healthcare team will follow combination protocols that are evidence-based and strict.

10. Does it need dose adjustment?

Patients with pre-existing renal impairment may possibly need considerably reduced dosages. The healthcare team will adhere to the dosing guidelines that have been adjusted.

11. Is it safe to use during pregnancy?

It may be used in pregnancy only when a life saving necessity. Obstetric and infectious disease specialist recommendations must be followed.

12. Does Colistin require a prescription?

Yes, it is a “last-resort” antibiotic, available on prescription for clinical use only.

Medical Disclaimer:

Colistin 3 MIU Injection is a prescription medicine and must be used only under the supervision and guidance of a qualified healthcare professional. Do not self medicate, alter the dose or stop taking the medication without talking to your doctor. The information provided here is for educational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Results, benefits and risks may vary from person to person. Always talk with your doctor before you start, change, or stop a medication.