Acaone 100mg Capsule

Acaone 100mg Capsule contains Acalabrutinib and is primarily used for the treatment of certain types of blood cancer.

Uses of Acaone 100mg Capsule

• Chronic lymphocytic leukemia (CLL)
• Small lymphocytic lymphoma (SLL)
• Mantle Cell Lymphoma (MCL)

How does the Acaone 100mg Capsule work?

Acalabrutinib is a selective BTK (Bruton’s tyrosine kinase) inhibitor. It inhibits BTK, which stops malignant B-cells from surviving and growing, thereby slowing the growth of cancer cells.

How to Use & Dosage

Take the capsules by mouth with water, with or without food, at the same time each day. The standard dose is 100 mg twice daily for CLL/SLL. The usual recommended dose for MCL is 100 mg twice daily or as directed by your physician.

Take this medicine with a full glass of water. Follow the instructions on your prescription label. Do not chew, cut, or break the capsules. Swallow them whole. Your healthcare team may adjust your dose or advise you to stop treatment if you experience side effects.

Do not stop taking this medicine or change your dose unless instructed by your healthcare provider. Avoid grapefruit and grapefruit juice while taking this medicine. Do not take antacids or H2-blockers within two hours of taking this medicine. Consult your healthcare provider before using this medicine in children. If you think you have taken too much of this medicine, contact your local emergency department or poison control center immediately.

Possible Side Effects

• Headache
• Diarrhea
• Fatigue
• Nausea
• Bruising
• Increased risk of bleeding
• Infections (due to immunosuppression)
• Heart rhythm problems (arrhythmias)

Safety Advice

⚠️ Liver

With the use of Acaone capsules, some patients may experience increased liver enzymes (AST and ALT). Regular monitoring is recommended. Please consult your healthcare provider.

🤰 Pregnancy

Using Acaone 100mg Capsule during pregnancy may be harmful. Kindly speak with your healthcare provider before using this medicine.

🤱 Breastfeeding

Acaone 100mg Capsule is not recommended for use while breastfeeding. The medicine may pass into breast milk and could harm a nursing infant. Please consult your healthcare provider.

🍺 Alcohol

It is unclear whether taking Acaone 100mg Capsule with alcohol is safe. Please consult your healthcare provider.

Storage Instructions

Store at room temperature (20°C to 25°C). Keep the capsules dry and store them in their original packaging away from direct sunlight. Keep out of the reach of children.

References

• FDA (AstraZeneca). CALQUENCE (acalabrutinib) Full Prescribing Information. 2026.
• Byrd JC, Harrington B, O’Brien S, et al. Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia. N Engl J Med. 2016;374(4):323-332.
• Wang M, Rule S, Zinzani PL, et al. Acalabrutinib in Relapsed or Refractory Mantle Cell Lymphoma (ACE-LY-004). Lancet. 2018;391(10121):659-667.
• Goodman & Gilman’s. The Pharmacological Basis of Therapeutics. 13th ed. New York: McGraw-Hill.
• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.

Disclaimer

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