Mabtas 500mg Injection

Mabtas 500mg Injection is a medicine that contains rituximab, a monoclonal antibody used in the treatment of certain types of cancer and autoimmune diseases.

Uses of Mabtas 500mg Injection

• Non-Hodgkin’s Lymphoma
• Chronic Lymphocytic Leukemia
• Rheumatoid Arthritis
• Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)
• Pemphigus Vulgaris

How does Mabtas 500mg Injection work?

Rituximab targets the CD20 antigen on the B-lymphocyte (B-cell) which is involved in normal immune function as well as in the development of certain cancers such as non-Hodgkin’s lymphoma and CLL. Rituximab binds to CD20 and causes B-cell death by several mechanisms including direct apoptosis (cell death), complement activation and immune cells to kill the antibody tagged B-cells.

How to Use & Dosage

You will receive this medicine from a health care professional in a hospital or clinic.

You will get a special Medication Guide before each treatment so read it carefully each time.

Discuss the use of this drug in children with your doctor. Although it may be prescribed to children as young as 6 months old for certain conditions, specific precautions must be taken.

If you overdose, call your poison control center or go to the emergency room.

Possible Side Effects

• Skin rash
• Itching
• Hives
• Swelling of the face, lips, or tongue
• Diarrhea
• Edema
• Weight gain
• Trouble breathing
• Irregular heartbeat
• Heart attack
• Fever
• Chills
• Cough
• Sore throat

Safety Advise

🫀 Liver

There is limited information available on the use of Mabtas 500mg Injection in patients with liver disease. Please talk to your healthcare provider.

🫘 Kidney

There is no information available on the use of Mabtas 500mg Injection in patients with renal impairment. Please consult your healthcare provider.

🤰 Pregnancy

Rituximab may cause fetal harm and should be used during pregnancy only if clearly needed. Please consult your healthcare provider.

🤱 Breastfeeding

Nursing Mothers: Do not take a 500mg Mabtas injection if not necessary. Please contact your health care provider.

🍺 Alcohol

It is recommended that you should be cautious while using Mabtas 500mg Injection with alcohol. Please consult your healthcare provider.

Storage Instructions

Store in a refrigerator, 2°C to 8°C. Do not shake or freeze the bottle.

References

• Genentech, Inc. RITUXAN (Rituximab) Injection: Highlights of Prescribing Information, Including Boxed Warning. U.S. Food and Drug Administration.
• Cheson BD, Leonard JP. Monoclonal Antibody Therapy for B-Cell Non-Hodgkin’s Lymphoma. New England Journal of Medicine. 2008;359(6):613-626.
• Stone JH, Merkel PA, Spiera R, et al. Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis. New England Journal of Medicine. 2010;363(3):221-232.
• Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.
• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.

Disclaimer

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