Arsenam 10mg Injection

Arsenam 10mg Injection Active Ingredient: Arsenic Trioxide. It is mainly used to treat acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). Arsenic trioxide causes immature blood cells to mature and it can induce apoptosis, or programmed cell death, in cells that have become cancerous.

Uses of Arsenam 10mg Injection

• Acute promyelocytic leukemia

How does the Arsenam 10mg Injection work?

Arsenic trioxide induces oxidative stress, disrupts the mitochondria of cells, and inhibits some proteins that are essential for the survival of cancer cells, thus targeting and inducing apoptosis in leukemic cells. It also affects differentiation of leukemia cells which leads to their maturation and final death.

How to Use & Dosage

The dosage and administration scheme depends on the body weight, the condition of the patient and the stage of treatment. It is given as an intravenous infusion under the supervision of a medical practitioner.

A doctor or nurse injects a solution (liquid) of arsenic trioxide into a patient’s vein in a clinic or doctor’s office. Arsenic trioxide injections are usually given over one to two hours. They may take up to four hours if side effects develop during the infusion. Generally, it is given one day in a fixed time span.

Possible Side Effects

• Fatigue
• Nausea
• Vomiting
• Diarrhea
• Skin rash
• Hyperglycemia
• Dizziness
• Fever
• Itching

Safety Advise

🫀 Liver

Caution in cases of impaired liver function, dose adjustment may be required. Consult your physician.

🫘 Kidney

Caution in patients with impaired renal function, dose adjustment may be required. Please discuss with your healthcare provider.

🤰 Pregnancy

It is not recommended for use during pregnancy as it may harm the fetus. Check with your health-care provider.

🤱 Breast Feeding

Nursing: Information on use of Arsenam 10mg Injection is not available. Discuss this with your health care provider.

🍺 Alcohol

It is not known if it is safe to drink alcohol with Arsenam 10mg Injection. Discuss with your health care provider.

Storage Instructions

Refrigerate at 2°C to 8°C (36°F to 46°F). Don’t freeze up. Store in the dark.

References

• Miller Jr WH, Schipper HM, Lee JS, Singer J, Waxman S. Mechanisms of action of arsenic trioxide. Cancer Research. 2002 Jul 15;62(14):3893-903.
• Antman KH. Introduction: the history of arsenic trioxide in cancer therapy. The Oncologist. 2001 Apr 1;6(S2):1-2.
• Litzow MR. Arsenic trioxide. Expert Opinion on Pharmacotherapy. 2008 Jul 1;9(10):1773-85.
• Davison K, Mann KK, Miller Jr WH. Arsenic trioxide: mechanisms of action. In Seminars in Hematology. 2002 Apr 1 (Vol. 39, No. 2, pp. 3-7). WB Saunders.

Disclaimer

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Manufacturer Details

Name: GLS Pharma Ltd.

Address: R-4, Khirki Main Road, Malviya Nagar, New Delhi – 110017, India

Country of origin: India