Ematra Softgel Capsule

Ematra Softgel Capsule is used for the treatment of acute promyelocytic leukaemia (APL), a sub-type of acute myeloid leukaemia. Ematra Softgel Capsule contains Tretinoin (All-Trans Retinoic Acid). Tretinoin works by prompting immature blood cells to mature into healthy, mature cells.

Uses of Ematra Softgel Capsule

• Acute promyelocytic leukemia

How does the Ematra Softgel Capsule work?

Tretinoin induces differentiation of immature carcinogenic cells and inhibits their growth by acting on certain receptors in these cells. Tretinoin helps to unblock the promyelocyte differentiation that is blocked by the PML-RARα fusion protein in APL, enabling the leukemic cells to mature into viable blood cells.

How to Use & Dosage

In general, two divided doses of approximately 45 mg/m² per day are recommended. The exact dosage will depend on the patient’s weight, health and course of therapy, commonly used for a period of 90 days or as directed by a physician.

Take this prescription with a glass of water. Take as directed on the medicine label. Follow your prescription medicine directions regularly. Do not use it more often than prescribed. Do not stop taking unless your care team tells you to.

Before giving this drug to a child, talk with the doctor. This medicine may be used for specific conditions; however, precautions are to be taken.

Possible Side Effects

• Headache
• Fever
• Nausea
• Vomiting
• Bone pain
• Dry lips
• Hair loss
• Visual impairment
• Skin dryness or rash
• Leukocytosis

Safety Advise

🫀 Liver

Liver damage is a possible side effect of treatment and liver function tests are mandatory. Please speak to your health care provider.

🫘 Kidney

However, regular renal function tests are needed as renal damage may occur during treatment. Please consult your healthcare provider.

🤰 Pregnancy

Retinoin is extremely teratogenic (may cause birth problems) and women of childbearing age must not become pregnant while on treatment and for a period of time after treatment. Please consult your health care provider.

🤱 Breast Feeding

Ematra capsules may not be safe to use during breastfeeding. It may have some effect on the baby if you are breastfeeding. Information: Ask your healthcare professional.

🍺 Alcohol

It is not known whether Ematra Capsule is safe to use with alcohol. Please check with your health care provider.

Storage Instructions

Store at room temperature between 15° and 25°C (59° and 77°F). Keep away from light.

References

• Gillis JC, Goa KL. Tretinoin: a review of its pharmacodynamic and pharmacokinetic properties and use in the management of acute promyelocytic leukaemia. Drugs. 1995 Nov;50:897-923.
• Warrell Jr RP, Frankel SR, Miller Jr WH, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A, Gabrilove J. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). New England Journal of Medicine. 1991 May 16;324(20):1385-93.
• Mahmoud HH, Hurwitz CA, Roberts WM, Santana VM, Ribeiro RC, Krance RA. Tretinoin toxicity in children with acute promyelocytic leukaemia. The Lancet. 1993 Dec 4;342(8884):1394-5.

Disclaimer

IHS Enterprises’s primary objective is to guarantee the accuracy, reliability, and specialist review of the information it provides to customers. The contents and information provided on this website are for informational purposes only. They should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician for guidance and any questions you may have about any condition or medication. If you do read anything from IHS Enterprises, please do not discount or delay in seeking competent medical advice. We want to enhance the doctor-patient relationship, not substitute it.

Manufacturer Details

Name: Emcure Pharmaceuticals Ltd

Address: 255/2, Hinjawadi, Pune – 411057, India

Country of origin: India