Aztrohigh 2gm Injection

Aztrohigh 2gm Injection is an Antibiotic injection and it contains Aztreonam. It is used to prevent or treat various bacterial infections like infections of the blood, brain, ears, skin, belly, bones, lungs and urinary tract.

Uses of Aztrohigh 2gm Injection:

• Infections caused by susceptible Gram-negative bacteria
• Urinary tract infections
• Respiratory tract infections
• Intra-abdominal infections
• Skin and soft tissue infections

How does Aztrohigh 2gm Injection work?

Aztreonam works by stopping the production of the bacterial cell wall. It binds to penicillin binding proteins in the bacterial cell wall and causes the cell to lyse and die . Its monobactam structure makes it resistant against several bacterial beta-lactamases and thus more effective against resistant strains.

How to Use & Dosage

Aztrohigh is typically given by a healthcare provider either as an intramuscular injection or as a slow infusion into a vein. Before giving the drug, it must be reconstituted and diluted correctly, following the manufacturer’s instructions.

The drug is given by injection into a vein or a muscle, usually by a health care professional in a hospital or clinic setting. If you get this medication at home, you will be told how to get it ready and give it.

Take as directed. Take at the same time each day as directed on the prescription label. Keep taking until your doctor tells you to stop. Be sure to throw away used needles and syringes in a special sharps container. If you do not have a sharps container, call your pharmacist or health care provider to get one.

If you think you have used too much of this medicine, call a poison control center or emergency room immediately.

Possible Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Rash
• Itching
• Fever
• Fatigue
• Injection site reactions (pain, redness, swelling)
• Allergic reactions (anaphylaxis)
• Liver enzyme elevations

Safety Advise:

🩺 Kidney

Use Aztrohigh 2gm with caution in patients with renal disease. The dosage of Aztrohigh may need to be altered. Please discuss with your doctor.

🫀 Liver

Caution should be exercised in patients with liver disease on Aztrohigh 2gm. The dose of Aztrohigh may need to be adjusted. Discuss with your healthcare provider.

🤰 Pregnancy

Aztrohigh should not be used during pregnancy as these are known to cause harm to the developing fetus. Please consult with your healthcare provider.

🤱 Breast-feeding

Aztrohigh is not recommended in breast feeding as it can be harmful and become poisonous in the fetus. Talk to your health care provider.

Storage Instructions

Store the product at room temperature in a dry environment away from moisture. Keep out of direct sunlight and store in original packaging.

References

1. AZACTAM® (aztreonam for injection, USP). Full Prescribing Information. Princeton, NJ: Bristol-Myers Squibb / Almirall.
2. Romano A, Gaeta F, Valluzzi RL, Alonzi C, Maggioletti M, Zaffiro A, Caruso C. Absence of Cross-Reactivity to Aztreonam in Patients with IgE-Mediated Hypersensitivity to β-Lactam Antibiotics. Journal of Allergy and Clinical Immunology. 2016;138(1):179-186.
3. Zhanel GG, Lawson CD, Adam H, et al. Ceftazidime-Avibactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination. Drugs. 2013;73(2):159-177. (useful comparative reference given aztreonam’s structural relationship to ceftazidime)
4. Sykes RB, Bonner DP. Aztreonam: The First Monobactam. American Journal of Medicine. 1985;78(2A):2-10.
5. Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.

Disclaimer:

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Manufacturer details

Name: Mankind Pharma Ltd

Address: 208, Okhla Industrial Estate, Phase III, New Delhi – 110020

Country of origin: India