Abiratas 500mg Tablet

Abiratas 500mg Tablet is an anti-cancer medicine used to treat metastatic castration-resistant prostate cancer (mCRPC). It contains Abiraterone acetate. It is a type of drug known as an androgen biosynthesis inhibitor, which works by preventing the production of androgens (male hormones like testosterone) that promote the growth of prostate cancer cells.

Uses of Abiratas 500mg Tablet

• Metastatic Castration-Resistant Prostate Cancer (mCRPC)
• Metastatic High-Risk Castration-Sensitive Prostate Cancer (mCSPC)

How does Abiratas 500mg Tablet work?

It inhibits the action of the CYP17A1 enzyme that is needed to make androgen (testosterone) in the adrenal glands, testes and prostate tumour tissues. Blocking this enzyme drastically lowers androgen levels, starving the prostate cancer cells of the hormones they need to grow. It is especially effective in the treatment of metastatic castration-resistant prostate cancer (mCRPC).

How to Use This Medication?

Take this medication by mouth on an empty stomach once daily 2 hours before or 1 hour after a meal. Do not chew or crush the tablets. Swallow the tablets whole. This will help to avoid further adverse effects.

Your dose is based on your medical condition, laboratory tests, how you are responding to treatment, and other medications you may be taking. Make sure to tell your doctor and chemist about all the products you use.

Taking this drug daily will get you the maximum benefit. Take it at the same time each day to help you remember. Do not stop taking any of your prostate cancer medications unless told to do so by your physician. You stop taking your meds and the cancer may spread faster.

Possible Side Effects

• Swelling
• Hypokalemia (low potassium)
• Hypertension (high blood pressure)
• Elevated liver enzymes
• Fatigue
• Joint pain
• Nausea
• Vomiting
• Anemia
• Diarrhea

Safety Advise

🩺 Kidney

Abiratas 500mg tablets should be used with caution in patients with severe renal disease. The dose of the Abiratas 500 mg tablet may need to be adjusted. Please talk to your doctor.

🧬 Liver

Abiratas 500mg tablets should be used with caution in patients with severe hepatic disease. The dose of the Abiratas 500 mg tablet may need to be changed. Please speak with your healthcare provider.

🤰 Pregnancy

Abiratas tablets are not recommended for use in pregnant women due to possible foetal harm. Please consult your health care provider.

🤱 Breastfeeding

Abiratas 500mg Tablet is not recommended for use while breastfeeding. Evidence suggests that the drug may be harmful to the foetus. Please consult your healthcare provider.

🍷 Alcohol

It is not known if it is safe to take Abiratas 500 mg tablets with alcohol. Please discuss this with your healthcare provider.

Storage Instructions

Store in a cool dry place below 30°C and away from moisture.

References

• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.
• Katzung BG, Vanderah TW. Basic and Clinical Pharmacology. 15th ed. New York: McGraw Hill.
• Attard G, Reid AH, Yap TA, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. Journal of Clinical Oncology. 2008;26(28):4563-4571.
• Auchus RJ, Yu MK, Nguyen S, Mundle SD. Use of prednisone with abiraterone acetate in metastatic castration-resistant prostate cancer. The Oncologist. 2014;19(12):1231-1240.
• Janssen Biotech, Inc. Zytiga (abiraterone acetate) Tablets Prescribing Information. Full Prescribing Information, U.S. Food and Drug Administration.

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