Bosutris 500mg Tablet

The active ingredient of Bosutris 500mg Tablet is Bosutinib. Bosutinib is a tyrosine kinase inhibitor (TKI) used to treat certain types of chronic myeloid leukemia (CML). It works by blocking the activity of the BCR-ABL protein that leads to abnormal growth of white blood cells in people with CML.

Uses of Bosutris 500mg Tablet

• Chronic myeloid leukemia

How does the Bosutris 500mg Tablet work?

Bosutinib inhibits the fusion protein BCR-ABL tyrosine kinase resulting from the Philadelphia chromosomal defect. Such inhibition contributes to the control of the disease by blocking the signaling pathways necessary to the growth and proliferation of leukemic cells.

How to Use & Dosage

100 mg to 500 mg once daily as needed depending on the patient’s medical condition and response to treatment. Tablets must be taken with food to increase absorption.

Bosutinib is given by mouth in the form of a tablet. It is usually taken once a day with food. Take bosutinib once daily at about the same time each day. Read the directions on your prescription label carefully, and ask your pharmacist or doctor to explain any part you do not understand. Bosutinib should be taken as directed. Never take more or less than your doctor has suggested or more often.

Do not chew, break or crush the tablets. Swallow them whole. Do not handle crushed or broken tablets with your bare hands.

Possible Side Effects

• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Fatigue
• Elevated liver enzymes
• Edema
• Headache
• Cough
• Fever
• Anemia

Safety Advise

🫀 Liver

Bosutinib can lead to increased liver enzymes and, in some cases, serious liver damage. Liver function tests should be done regularly. Please speak with your healthcare provider.

🫘 Kidney

Patients with renal impairment may require dose changes. Please speak to your healthcare provider.

🤰 Pregnancy

Not recommended in pregnancy due to possible risk to the fetus. Please discuss with your health care provider.

🤱 Breastfeeding

Use of Bosutris 400 Tablet in nursing mothers is likely unsafe. Please consult your healthcare provider.

🍺 Alcohol

There is no information available on the effect of taking alcohol with Bosutris 400 Tablets. Please consult your health care provider.

Storage Instructions

Store at room temperature, usually 15°C to 30°C (59°F to 86°F). Store the pills in their original container to protect them from light and moisture.

References

• Keller G, Schafhausen P, Brümmendorf TH. Bosutinib. Small Molecules in Oncology. 2010:119-27.
• Abbas R, Hsyu PH. Clinical pharmacokinetics and pharmacodynamics of bosutinib. Clinical Pharmacokinetics. 2016 Oct;55:1191-204.
• Kantarjian HM, Cortes JE, Kim DW, Khoury HJ, Brümmendorf TH, Porkka K, Martinelli G, Durrant S, Leip E, Kelly V, Turnbull K. Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors. Blood. 2014 Feb 27;123(9):1309-18.
• Stansfield L, Hughes TE, Walsh-Chocolaad TL. Bosutinib: a second-generation tyrosine kinase inhibitor for chronic myelogenous leukemia. Annals of Pharmacotherapy. 2013 Dec;47(12):1703-11.

Disclaimer

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Manufacturer Details

Name: Mylan Pharmaceuticals Pvt Ltd – A Viatris Company

Address: Mylan Pharmaceuticals Private Limited, Commercial Operations, Prestige Tech Park, Platina-3, 7th to 12th Floor, Prestige Tech Park, Kadubesanahalli, Bangalore – 560103

Country of origin: India