Cabolong 40mg Tablet

Cabolong 40mg Tablet is composed of: Cabozantinib (40mg). Cabotinib is a tyrosine kinase inhibitor (TKI) that blocks many receptor tyrosine kinases (RTKs) involved in tumour growth, metastasis and angiogenesis, and is used to treat a wide range of cancers.

Uses of Cabolong 40mg Tablet

• Liver Cancer
• Kidney Cancer
• Medullary thyroid Cancer

How does a Cabolong 40mg Tablet work?

Cabotinib inhibits several tyrosine kinases including MET, VEGFR and RET that are involved in several pathways that are important for tumour cell growth and angiogenesis (formation of blood vessels). Cabozantinib blocks these kinases which can reduce the blood supply to the tumor and inhibit cancer cell growth and spread.

How to Use & Dosage

Cabozantinib is a pill that you usually take once a day on an empty stomach, either 1 hour before or 2 hours after a meal. Listen to your doctor carefully and do not change the dose without your doctor’s advice.

Take the tablets with a full glass of water. Do not crush, chew, split or open them.

The usual dose of Cabolong is 40 – 60 mg once daily. The dose depends on the type of cancer being treated and patient factors such as liver or renal function. To be taken at least 2 hours before or after a meal, on an empty stomach.

Possible Side Effects

• Diarrhea
• Fatigue
• Nausea
• Vomiting
• Anemia
• Decreased appetite
• Weight loss
• Elevated liver enzymes
• Hypertension (high blood pressure)
• Palmar-plantar erythrodysesthesia (hand-foot syndrome)

Safety Advise

🫘 Kidney

Renal impairment: dose adjustment may be needed and renal function should be monitored regularly. Please talk to your health care provider.

🫀 Liver

Dose adjustments may be needed in patients with liver impairment and periodic liver function tests are recommended. Please talk to your healthcare provider.

🤰 Pregnancy

Cabozantinib is not recommended during pregnancy because of the potential to harm the fetus. Please talk to your healthcare provider.

🤱 Breastfeeding

Cabolong 40mg Tablet is likely unsafe to use while breastfeeding. Please speak to your health care provider.

🍺 Alcohol

It is not known if it is safe to take a Cabolong 40mg Tablet with alcohol. Consult your health care provider.

Storage Instructions

Store at room temperature between 15°C and 30°C (59°F and 86°F). Store in a dry place, away from direct light and moisture.

References

• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.
• Katzung BG, Vanderah TW. Basic and Clinical Pharmacology. 15th ed. New York: McGraw Hill.
• Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Molecular Cancer Therapeutics. 2011;10(12):2298-2308.
• Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. Journal of Clinical Oncology. 2013;31(29):3639-3646.
• Exelixis, Inc. Cabometyx (cabozantinib) Tablets Prescribing Information. Full Prescribing Information, U.S. Food and Drug Administration.

Disclaimer

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Manufacturer Details

Name: MSN Laboratories

Address: MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad – 18, Telangana, INDIA

Country of origin: India