Cazanat 40mg Tablet

Cazanat 40mg Tablet is a medicine which has Cabozantinib as an active element. Cabotinib is a tyrosine kinase inhibitor (TKI) that has been used to treat various cancer types by targeting many receptor tyrosine kinases (RTKs) that are involved in tumour growth, metastasis, and angiogenesis.

Uses of Cazanat 40mg Tablet

• Liver Cancer
• Kidney Cancer
• Medullary thyroid Cancer

How does the Cazanat 40mg Tablet work?

Cabotinib blocks several tyrosine kinases including MET, VEGFR and RET which are involved in several pathways which are essential for tumor cell development and angiogenesis (creation of blood vessels). Cabozantinib can block these kinases to reduce the blood supply to tumors and slow the growth and spread of cancer cells.

How to Use & Dosage

The usual dosage of Cazanat is 40 mg once daily, depending on the cancer being treated and patient characteristics such as liver or renal function. It should be taken on an empty stomach, at least two hours before or after food.

Cabozantinib is a pill that is typically given once a day, either one hour before or two hours after meals, on an empty stomach. Pay close attention to what your doctor tells you, and don’t change the dosage without consulting your doctor.

Drink a full glass of water and swallow the tablets whole. Avoid opening, crushing, chewing, and splitting them.

Possible Side Effects

• Diarrhea
• Fatigue
• Nausea
• Vomiting
• Anemia
• Decreased appetite
• Weight loss
• Elevated liver enzymes
• Hypertension (high blood pressure)
• Palmar-plantar erythrodysesthesia (hand-foot syndrome)

Safety Advise

🫀 Liver

Patients with liver problems may require dose adjustments and regular liver function tests should be done. Please speak with your health care provider.

🫘 Kidney

Dose adjustment and routine monitoring of renal function may be required in patients with renal impairment. Please talk to your doctor.

🤰 Pregnancy

Cabozantinib is not recommended in pregnancy as it may harm the fetus. Please talk to your health care provider.

🤱 Breast feeding

Cazanat 40mg Tablet probably unsafe during breastfeeding. Discuss with your health care provider.

🍺 Alcohol

Cazanat 40mg Tablet is probably unsafe to use during pregnancy. Please consult with your physician.

Storage Instructions

Store at 15°C-30°C (59°F-86°F). Store in a dry place, away from light and moisture.

References

• Exelixis, Inc. CABOMETYX (Cabozantinib) Tablets: Highlights of Prescribing Information. U.S. Food and Drug Administration.
• Choueiri TK, Escudier B, Powles T, et al. Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma. New England Journal of Medicine. 2015;373(19):1814-1823.
• Abou-Alfa GK, Meyer T, Cheng AL, et al. Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma. New England Journal of Medicine. 2018;379(1):54-63.
• Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.
• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.

Disclaimer

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Manufacturer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India