Cefactiv 2.5gm Injection

Cefactiv 2.5gm Injection is an Antibiotic Injection and it is used for the treatment of serious bacterial infections of stomach, urinary system and lungs and it contains Ceftazidime, Avibactam. It is used to treat a variety of infections in adults and children, either alone or together with other antibiotics such as metronidazole.

Uses of Cefactiv 2.5gm Injection:

• Urinary tract infections
• Intra-abdominal infections
• Hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia.

How does Cefactiv 2.5gm Injection work?

Ceftazidime is a third-generation cephalosporin antibiotic that stops the formation of the bacterial cell wall and causes cell lysis and death. Avibactam is a non-beta-lactam beta-lactamase inhibitor that functions by shielding ceftazidime from degradation by certain enzymes produced by resistant bacteria. This enhances the effect of ceftazidime in combating infections caused by beta-lactamase producing organisms.

How to Use & Dosage

Given intravenously, usually over the period of 2 hours. Dose and duration depend on the type and severity of infection and patient factors such as renal function.

It is given into a vein or a muscle every 8 to 12 hours. The dose for children is based on their weight and medical condition. Ensure no particles or discolouration are present before use and consult your healthcare provider for proper preparation and storage. If using a pre-mixed solution which has been frozen, defrost at room temperature or in the fridge and shake well. For best effect, give the antibiotic at evenly spaced intervals.

Possible Side Effects:

• Fatigue
• Hot flashes
• Hypertension
• Nausea
• Vomiting
• Allergic reactions (anaphylaxis)
• Renal impairment
• Seizures

Safety Advise:

🩺 Kidney

Cefactiv 2.5gm Injection is safe for patients with renal disease to take. Take Cefactiv 2.5gm Injection as prescribed by your doctor.

🤰 Pregnancy

Cefactiv 2.5gm Injection should not be used during pregnancy. Talk to your doctor. Studies in pregnant women and animals have shown a significant risk to the developing infant.

🤱 Breastfeeding

Cefactiv 2.5gm Injection should not be used during breast feeding. Data suggest the medicine could be harmful to the infant.

Storage Instructions

Store in a cool, dry place, away from direct sunlight. After reconstitution store as stated in product literature.

References

1. AVYCAZ® (ceftazidime and avibactam) for Injection, for Intravenous Use. Full Prescribing Information. Silver Spring, MD: U.S. Food and Drug Administration.
2. Sharma R, Eun Park T, Moy S. Ceftazidime-Avibactam (Avycaz): For the Treatment of Complicated Intra-Abdominal and Urinary Tract Infections. Pharmacy and Therapeutics. 2016;41(1):11-14.
3. Wagenlehner FM, Sobel JD, Newell P, et al. Ceftazidime-Avibactam Versus Doripenem for the Treatment of Complicated Urinary Tract Infections, Including Acute Pyelonephritis: RECAPTURE, a Phase 3 Randomized Trial Program. Clinical Infectious Diseases. 2016;63(6):754-762.
4. Torres A, Zhong N, Pachl J, et al. Ceftazidime-Avibactam Versus Meropenem in Nosocomial Pneumonia, Including Ventilator-Associated Pneumonia (REPROVE): A Randomised, Double-Blind, Phase 3 Non-Inferiority Trial. The Lancet Infectious Diseases. 2018;18(3):285-295.
5. Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.

Disclaimer:

IHS Enterprises’s primary objective is to guarantee the accuracy, reliability, and specialist review of the information it provides to customers. The contents and information provided on this website are for informational purposes only. They should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician for guidance and any questions you may have about any condition or medication. If you do read anything from IHS Enterprises, please do not discount or delay in seeking competent medical advice. We want to enhance the doctor-patient relationship, not substitute it.

Frequently Asked Questions (FAQs):

1. What is Cefactiv 2.5gm Injection?

Cefactiv 2.5gm is a combination of Antibiotic Injection which contains Cefoperazone (2g) and Sulbactam (1g). It can be used to treat serious infections due to susceptible bacteria, particularly in a hospital setting.

2. How does Cefactiv work?

Cefoperazone is a third generation cephalosporin antibiotic that may inhibit bacterial cell wall synthesis which may result in cell death of susceptible organisms. Sulbactam is a beta-lactamase inhibitor and may protect Cefoperazone from bacterial resistance enzymes and increase its antibacterial coverage.

3. What infections is Cefactiv used to treat?

Cefactiv may be used to treat infections such as:

• Hospital acquired pneumonia
• Urinary tract infections
• Intra-abdominal infections (eg, peritonitis, biliary tract infections)
• Gynaecological infections
• Skin and soft tissue infection
• Bacteraemia (blood stream infections)

The efficacy depends on the susceptibility of the causative organism as determined by culture and sensitivity testing.

4. How is Cefactiv 2.5gm given?

It is given by a health care professional as an intravenous (IV) infusion or an intramuscular (IM) injection in a hospital or clinic.

5. What is the usual dose of Cefactiv?

The usual dose for adults is 2.5 g every 12 hours, which can be increased to every 8 hours in more severe infections. Hepatic or renal impairment: Dose adjustment may be needed in patients with hepatic or renal impairment. Follow the advice of your doctor.

6. What are the possible side effects of Cefactiv?

Some patients may receive:

• Diarrhoea (including, rarely, colitis associated with Clostridioides difficile)
• Rash
• Elevated liver enzymes
• Injection site reactions
• Nausea or vomiting

Tell your doctor right away if you have any of these side effects that are especially bothersome or do not go away.

7. Can Cefactiv be used in patients who are allergic to penicillin?

Cross-reactivity between penicillins and cephalosporins is possible, but the risk is considered low. If you are known to be allergic to penicillin, it is very important to tell your doctor before taking Cefactiv so that an appropriate risk assessment can be made.

8. Does Cefactiv have any interaction with alcohol?

In some patients taking cefoperazone, drinking alcohol may cause a disulfiram-like reaction with flushing, nausea, vomiting and rapid heartbeat. Do not drink alcohol during your treatment and for a few days after your last dose.

9. Is Cefactiv safe to use during pregnancy?

Use during pregnancy should be reserved only for situations where the potential benefit justifies the potential risk to the fetus as determined by a physician. If you are pregnant or breast-feeding, discuss with your doctor the safety of this injection before you receive it.

10. Is Cefactiv a prescription only drug?

Yes. Cefactiv 2.5gm is an injectable antibiotic and is only available on prescription. It can only be given in a hospital or clinical setting by a physician.

Medical Disclaimer

Cefactiv 2.5gm Injection is a prescription medicine. Use it as directed by your doctor. Do not self-medicate, change the dose or discontinue use without consulting your doctor. The material appearing on this site is for educational purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment. Results, benefits and risks are variable and individual. Always consult your doctor before you start, stop, or change any medications or supplements.

Manufacturer details

Name: Glenmark Pharmaceuticals Ltd

Address: Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.

Country of origin: India