Dyronib 70mg Tablet

Dyronib 70mg Tablet contains Dasatinib, which is used to treat chronic myeloid leukemia and certain types of acute lymphoblastic leukemia, especially in patients who are unable to use other medications due to side effects.

Uses of Dyronib 70mg Tablet

• Chronic Myeloid Leukemia (CML)
• Acute Lymphoblastic Leukemia (ALL)

How does the Dyronib 70mg Tablet work?

Dasatinib is a tyrosine kinase inhibitor (TKI) that targets BCR-ABL, the abnormal protein produced by the Philadelphia chromosome. It blocks the signals that promote the growth and proliferation of cancer cells, leading to their death.

How to Use & Dosage

Dyronib is taken orally with or without food. For CML, the recommended starting dose is 100 mg once daily. For ALL, the recommended dose is generally 140 mg once daily. The dose may be adjusted based on clinical response and tolerability.

Take this medication with a full glass of water exactly as directed. It may be taken with or without food, but avoid grapefruit and grapefruit juice. Do not chew or cut the tablet. Take it regularly as prescribed. Avoid antacids containing aluminum, calcium, or magnesium for two hours before or after taking this medicine. Discuss the use of this medicine in children with your healthcare provider.

Possible Side Effects

• Diarrhea
• Nausea
• Fatigue
• Headache
• Rash
• Myelosuppression (low blood cell counts)
• Pleural effusion
• Cardiac issues (such as arrhythmias)

Safety Advice

🫁 Lung

It is not known if Dyronib is safe to use in people with breathing problems. Please discuss this with your healthcare provider.

🤰 Pregnancy

Dyronib 70mg Tablet should not be used during pregnancy, as there is clear evidence of risk to the developing fetus. Please consult your healthcare professional.

🤱 Breast Feeding

Dyronib 70mg Tablet is not recommended while breastfeeding. The medicine may pass into breast milk and could harm a nursing infant. Please consult your healthcare provider.

🍺 Alcohol

It is not known whether it is safe to consume alcohol while taking Dyronib 70mg Tablet. Please speak with your healthcare provider.

🚗 Driving

Dyronib 70mg Tablet may cause side effects such as dizziness or blurred vision that can affect your ability to drive or operate machinery. If you experience these symptoms, do not drive. Please consult your healthcare professional.

Storage Instructions

Store at room temperature (20°C to 25°C) in a dry place away from moisture and direct sunlight. Keep the tablets in their original packaging and out of the reach of children.

References

• FDA (Bristol-Myers Squibb). SPRYCEL (dasatinib) Full Prescribing Information. 2024.
• Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in Imatinib-Resistant Philadelphia Chromosome-Positive Leukemias. N Engl J Med. 2006;354(24):2531-2541.
• Kantarjian H, Cortes J, Kim DW, et al. Phase 3 Study of Dasatinib 140 mg Once Daily Versus 70 mg Twice Daily in Patients With Chronic Myeloid Leukemia. Blood. 2009;113(25):6322-6329.
• Goodman & Gilman’s. The Pharmacological Basis of Therapeutics. 13th ed. New York: McGraw-Hill.
• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.

Disclaimer

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