Elistin MX 4.5 MIU Injection

Elistin MX 4.5 MIU Injection is a polymyxin antibiotic. It contains Colistimethate Sodium. It is indicated for the treatment of serious infections due to multi drug resistant Gram-negative bacteria. This is often a last resort when other antibiotics don’t work, usually in a hospital.

Uses of Elistin MX 4.5 MIU Injection:

• Severe Bacterial Infections

How does Elistin MX 4.5 MIU Injection work?

Colistin sodium is an inactive prodrug that the body converts to its active form after administration. Colistin is bactericidal by binding to phospholipids and lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria. This binding disrupts the cell membrane and makes it more permeable. This increased permeability allows cellular contents to flow out of the cell, leading to bacterial cell death.

How to Use & Dosage

Dosage is affected by the severity of the infection, the patient’s body weight and renal function. It must be closely watched by healthcare practitioners in order to adjust for toxicity risk and therapeutic response.

Colistimethate injections are usually given every 6 to 12 hours as a muscle injection or as a powder and liquid mixture injected intravenously over a period of 3 to 5 minutes. The length of therapy depends upon your health, the type of illness, and how well you respond to the drug. It may also be given as a continuous infusion over 22-23 hours.

Even if you feel better, keep using the colistimethate injection until the full prescription is finished. If you do not finish the colistimethate injection treatment or take the drug at the same time each day, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Possible Side Effects:

• Dizziness
• Tingling
• Muscle weakness
• Nausea
• Vomiting
• Skin Rash
• Itching
• Diarrhea
• Kidney Damage

Safety Advise:

🫁 Lungs

Safety of Elistin Injection in patients with lung problems is not known. Please consult your health care provider.

🫀 Liver

Safety of Elistin Injection in patients with liver disease is unknown. Please contact your healthcare provider.

🩺 Kidney

Elistin Injection is not known if it is safe and effective in patients with Kidney problems. Please talk to your health care provider.

🤰 Pregnancy

Use Elistin in pregnancy only if clearly needed. Discuss the risks and benefits with your doctor.

🤱 Breast Feeding

It is probably not safe to use Elistin when you are pregnant. Please talk to your health care provider.

Storage Instructions:

Store the vial at 2°C to 8°C. Store in original packaging protected from light. Do not freeze.

References

1. Tsuji BT, Pogue JM, Zavascki AP, et al. International Consensus Guidelines for the Optimal Use of the Polymyxins. Pharmacotherapy. 2019;39(1):10–39.
2. Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.
3. British National Formulary (BNF). Colistimethate Sodium. London: BMJ Group and Pharmaceutical Press.
4. Yendewa GA, Griffiss JM, Gray WA, et al. Dosing Colistimethate Every 8 h Results in Higher Plasma Concentrations of Active Colistin Than Every 12-Hourly Dosing without Increase in Nephrotoxicity: A Phase 1 Pharmacokinetics Trial in Healthy Adult Volunteers. Antibiotics. 2022;11(4):490.
5. Electronic Medicines Compendium (emc). Colomycin 1 Million International Units (IU) Powder for Solution for Injection, Infusion or Inhalation: Summary of Product Characteristics.

Disclaimer:

IHS Enterprises’s primary objective is to guarantee the accuracy, reliability, and specialist review of the information it provides to customers. The contents and information provided on this website are for informational purposes only. They should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician for guidance and any questions you may have about any condition or medication. If you do read anything from IHS Enterprises, please do not discount or delay in seeking competent medical advice. We want to enhance the doctor-patient relationship, not substitute it.