Emrok O Tablet

Emrok O Tablet is a broad-spectrum antibiotic belonging to the fluoroquinolone class and contains Levonadifloxacin. Levonadifloxacin is primarily indicated for the treatment of serious bacterial infections caused by resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA).

Uses of Emrok O Tablet:

• Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
• Community-Acquired Bacterial Pneumonia

How does Emrok O Tablet work?

Levonadifloxacin is a novel fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, which are critical enzymes for bacterial DNA replication, transcription, repair and recombination. This dual inhibition acts to kill bacteria and prevent the spread of infection.

How to Use & Dosage

Emrok O Tablet should be taken as per physician’s prescription. It can be taken with or without food. Swallow the tablet whole with a full glass of water. If you break, chew or crush the tablet, the drug may not work properly.

This medication is used orally as directed by your doctor. The quantity and length of treatment will depend on your condition and how you respond to it. Children’s weight also affects the dosage.

Continue taking this medication until the full suggested dosage is reached, even if symptoms disappear in a few days. If treatment is discontinued too soon, an infection may return.

Possible Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness
• Tremors
• Seizures
• Burning, itching at the injection site

Safety Advise:

🫀 Liver

Dose adjustment in patients with impaired liver function regular monitoring of function tests is recommended. Please discuss with your health care provider.

🩺 Kidney

Dose should be adjusted in patients with impaired renal function, renal function tests should be monitored regularly. Please speak with your healthcare provider.

🤰 Pregnancy

Not recommended during pregnancy unless necessary due to potential harm to the fetus. Please contact your health care provider.

🤱 Breast Feeding

Not recommended while breastfeeding unless necessary as it may be harmful to the growing baby. Please check with your health care provider.

Storage Instructions

Keep out of direct sunlight and moisture and store at room temperature. Don’t use after the expiration date and keep out of children’s reach.

References:

1. EMROK / EMROK-O (Levonadifloxacin / Alalevonadifloxacin) Prescribing Information. Mumbai: Wockhardt Ltd. (confirm against the CDSCO-approved Indian label, as this drug is not FDA-approved)
2. Bhatia A, Mastim M, Shah M, et al. Efficacy and Safety of Levonadifloxacin in the Treatment of Acute Bacterial Skin and Skin Structure Infections: A Phase 3 Randomized Controlled Trial. Journal of the Association of Physicians of India. 2020;68(11):30-36.
3. Patel K, Goldman JL. Safety Concerns Surrounding Quinolone Use in Children. Journal of Clinical Pharmacology. 2016;56(9):1060-1075. (useful general fluoroquinolone class-safety reference given levonadifloxacin’s newer/limited independent safety data)
4. Vidaillac C, Chotirmall SH. Levofloxacin: A Comprehensive Review of Its Pharmacokinetic and Pharmacodynamic Profile. Expert Review of Respiratory Medicine. 2018;12(2):97-111. (class-representative fluoroquinolone reference for tendon/QT/CNS class warnings, given levonadifloxacin is newer and less independently studied)
5. Bhatia A, Kumar BK, Kumar S, et al. Discovery and Development of Levonadifloxacin (WCK 771) and Its Prodrug Alalevonadifloxacin (WCK 2349): A First-in-Class Novel Broad-Spectrum Anti-MRSA Fluoroquinolone. ACS Omega. 2023;8(5):4239-4255. (mechanism/development reference)

Disclaimer:

IHS Enterprises’s primary objective is to guarantee the accuracy, reliability, and specialist review of the information it provides to customers. The contents and information provided on this website are for informational purposes only. They should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician for guidance and any questions you may have about any condition or medication. If you do read anything from IHS Enterprises, please do not discount or delay in seeking competent medical advice. We want to enhance the doctor-patient relationship, not substitute it.

Manufacturer details

Name: Wockhardt Ltd

Address: Wockhardt Towers, Bandra Kurla Complex, Bandra (East), Mumbai 400051, Maharashtra, India

Country of origin: India