Endace 40mg Tablet

Endace 40mg Tablet contains the active ingredient Megestrol Acetate, a synthetic form of the hormone progesterone (progestin). It is commonly used in the treatment of certain cancers, including breast and endometrial cancer, and may also be prescribed to help stimulate appetite and manage weight loss in specific medical conditions.

Uses of Endace 40mg Tablet

• Endometrial Cancer
• Breast Cancer

How does the Endace 40mg Tablet work?

Megestrol Acetate is a synthetic progestin that binds to progesterone receptors. It reduces the secretion of gonadotropin hormones (FSH and LH) from the pituitary gland, thereby lowering estrogen production. It may also stimulate appetite by acting on the hypothalamus and has anti-estrogenic properties, making it useful in managing cancer-related weight loss and appetite loss.

How to Use & Dosage

The usual starting dose is 40mg once daily, although your doctor may increase or decrease the dose depending on your medical condition and response to treatment.

Take Endace 40mg Tablet by mouth at the same time each day, exactly as prescribed by your healthcare provider. Do not change the dose or stop taking the medicine without consulting your doctor.

Possible Side Effects

• Weight gain
• Increased appetite
• Nausea
• Stomach upset
• Vomiting
• Constipation
• Hot flashes
• Blood clots (deep vein thrombosis, pulmonary embolism)
• Hyperglycemia
• Adrenal insufficiency

Safety Advice

❤️ Heart

Fluid retention and swelling (edema) may occur while taking Megestrol Acetate, which can worsen conditions such as high blood pressure, stroke, or heart disease. Patients with a history of these conditions should use this medicine cautiously. Please consult your healthcare provider.

🦴 Bone

Long-term use may reduce bone mineral density and increase the risk of osteoporosis and fractures. Please discuss this with your healthcare provider.

⚠️ Liver

Patients with liver disease should inform their doctor before starting treatment. Regular liver function tests may be recommended during therapy.

🩺 Kidney

Endace 40mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be required. Please consult your healthcare provider.

🤰 Pregnancy

Endace 40mg Tablet should not be used during pregnancy because it may cause harm to the unborn baby, including birth defects or miscarriage. Please consult your healthcare provider.

🤱 Breast Feeding

Megestrol Acetate may pass into breast milk and could harm a nursing infant. Breastfeeding is not recommended while taking this medicine. Please consult your healthcare provider.

🍺 Alcohol

It is not known whether alcohol interacts with Endace 40mg Tablet. Please consult your healthcare provider before consuming alcohol.

🚗 Driving

Endace 40mg Tablet may cause dizziness or fatigue in some patients. Avoid driving or operating machinery until you know how this medicine affects you.

Storage Instructions

Store below 25°C in a cool, dry place. Protect the tablets from moisture and direct light. Keep out of the reach of children.

References

• Schacter L, Rozencweig M, Canetta R, Kelley S, Nicaise C, Smaldone L. Megestrol Acetate: Clinical Experience. Cancer Treatment Reviews. 1989;16(1):49-63.
• Canetta R, Florentine S, Hunter H, Lenaz L. Megestrol Acetate. Cancer Treatment Reviews. 1983;10(3):141-157.
• Loprinzi CL, Michalak JC, Quella SK, et al. Megestrol Acetate for the Prevention of Hot Flashes. N Engl J Med. 1994;331(6):347-352.
• Tchekmedyian NS, Hickman M, Siau J, et al. Megestrol Acetate in Cancer Anorexia and Weight Loss. Cancer. 1992;69(5):1268-1274.

Disclaimer

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