Glioz 100mg Capsule

Glioz 100mg Capsule is an oral chemotherapy drug that contains Temozolomide, an alkylating agent, and is used primarily to treat certain types of brain cancer. Temozolomide prevents cancer cells from growing and spreading in the body.

Uses of Glioz 100mg Capsule

• Glioblastoma Multiforme
• Anaplastic Astrocytoma

How does Glioz 100mg Capsule work?

Temozolomide is an alkylating agent that adds alkyl groups to the DNA of cancer cells and interferes with their replication. This causes damage to DNA leading to cell cycle arrest and apoptosis (cell death). It is especially effective against fast-growing cancer cells.

How to Use & Dosage

The dose is based on the body surface area and the type of cancer that is being treated. Take by mouth with a full glass of water, either on an empty stomach or at bedtime to help lessen nausea. Do not open or crush capsules.

Take temozolomide capsules once a day at bedtime on an empty stomach with water, at about the same time each day. Follow your doctor’s advice on treatment cycles, because the timing of doses will depend on the type of brain tumor and on how you respond to treatment.

Your entire dosage may be in more than one prescription bottle, and of more than one type and color of capsule. Follow the directions on your prescription label carefully. Ask your pharmacist or doctor to explain any part you do not understand.

Possible Side Effects

• Nausea
• Vomiting
• Fatigue
• Headache
• Constipation
• Loss of appetite.
• Anemia
• Neutropenia
• Thrombocytopenia
• Severe infections
• Stevens-Johnson syndrome

Safety Advise

🫀 Liver

Temozolomide can be hepatotoxic and liver function tests should be monitored. You should talk to your health care provider.

🤰 Pregnancy

Temozolomide is teratogenic and contraindicated in pregnancy. Please speak with your healthcare provider.

🤱 Breastfeeding

Do not use Glioz 100mg Capsules while breast-feeding. Evidence suggests the drug may be harmful to the unborn child. Speak with your healthcare provider.

🍺 Alcoholic

It is not known if it is safe to drink alcohol with Glioz 100mg Capsules. Please consult your healthcare provider.

Storage Instructions

Store at 15-30°C (59-86°F). Keep the container tightly closed. Protect from moisture, heat and light. Store capsules in the original container tightly closed.

References

• Merck & Co., Inc. TEMODAR (Temozolomide) Capsules and for Injection: Highlights of Prescribing Information. U.S. Food and Drug Administration.
• Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma. New England Journal of Medicine. 2005;352(10):987-996.
• Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C. Temozolomide: A Review of its Discovery, Chemical Properties, Pre-Clinical Development and Clinical Trials. Cancer Treatment Reviews. 1997;23(1):35-61.
• Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.
• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.

Disclaimer

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