Nuparp 300mg Tablet

Nuparp 300mg Tablet is used for the treatment of cancer and contains rucaparib, a PARP inhibitor. It may help prolong responses to other treatments in people with recurrent ovarian, fallopian tube and primary peritoneal cancers who have responded to chemotherapy.

Uses of Nuparp 300mg Tablet:

• Ovarian cancer
• Prostate cancer

How does an Nuparp 300mg Tablet work?

Rucaparib works by inhibiting PARP enzymes, which are essential in DNA repair. When these enzymes are blocked, it causes the cells to die. Cancer cells can not repair their DNA. This is especially the case for cells that already lack DNA repair systems (e.g., cells with a BRCA mutation).

How to Use & Dosage

The usual dose is 300 mg once daily but may be adjusted according to the patient’s blood counts, weight and general condition. Route of administration Oral route.

Nuparp is to be taken by mouth, with the pills swallowed whole and not broken, crushed or chewed as directed. You can take it with or without food but if it upsets your stomach you may want to take it with food. Continue to take the medicine until your doctor tells you to stop.

Discuss with your doctor the use of this drug in children. Ask your health care provider about this medication’s use in children. Even if this drug is recommendable for some diseases, precautions are necessary.

If you think you have taken too much of this drug, call a poison control center or emergency room right away.

Possible Side Effects:

• Nausea
• Vomiting
• Fatigue
• Diarrhea
• Dizziness
• Anemia (low red blood cell count)
• Liver enzyme elevations

Safety Advise:

🫘 Kidney

Nuparp 300mg tablets should be used with caution in patients with renal disease. You may need to adjust the dose of your Tablets. Please discuss with your healthcare provider.

🫁 Lungs

Nuparp 300mg tablets safe to be administered in lung diseases patients is unknown. Talk to your health care provider.

🤰 Pregnancy

Nuparp 300mg tablets should not be used during pregnancy as it may affect the developing fetus. Talk with your health care provider.

🤱 Breast feeding

There is no information regarding the use of Nuparp 300mg tablets in breastfeeding. Please discuss with your healthcare provider.

🍷 Alcohol

It is not known whether it is safe to take Nuparp 300mg tablets with alcohol. Discuss with your healthcare provider.

Storage Instructions:

Store at 20 to 25°C (68 to 77°F). Protect from light. Do not freeze.

References

Clovis Oncology, Inc. RUBRACA (Rucaparib) Tablets: Highlights of Prescribing Information. U.S. Food and Drug Administration.

Coleman RL, Oza AM, Lorusso D, et al. Rucaparib Maintenance Treatment for Recurrent Ovarian Carcinoma After Response to Platinum Therapy (ARIEL3). The Lancet. 2017;390(10106):1949-1961.

Abida W, Patnaik A, Campbell D, et al. Rucaparib in Men with Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration. Journal of Clinical Oncology. 2020;38(32):3763-3772.

Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.

Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.

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