Pegstim 6mg Injection

Pegstim Injection contains Pegfilgrastim, a longer-acting form of filgrastim, a granulocyte colony-stimulating factor (G-CSF). Pegfilgrastim is primarily used to decrease the risk of infection in patients who are undergoing chemotherapy by stimulating the bone marrow to produce more white blood cells (neutrophils).

Uses of Pegstim 6mg Injection

• Chemotherapy-Induced Neutropenia
• Bone Marrow Transplantation

How does Pegstim 6mg Injection work?

Pegylated filgrastim is a pegylated form of filgrastim that promotes the growth, maturation, and activation of neutrophils, a type of white blood cell produced in the bone marrow. This reduces the risk of infection by shortening the period of neutropenia, or low neutrophil count, associated with chemotherapy.

How to Use & Dosage

Given as a single subcutaneous injection for each cycle of chemotherapy, usually 24 hours after completion of chemotherapy.

This medicine is injected under the skin. If you are using the pre-filled syringe or On-body Injector at home, be sure to follow the instructions provided carefully and tell your healthcare team right away if you think you missed a dose or received only part of a dose.

It is important that you place used needles and syringes in a special container called a sharps container. Never dispose of them in a regular garbage bin. If you do not have a sharps container, ask your pharmacist or healthcare provider for one.

Ask your healthcare provider about using this medicine in children. Special precautions may apply even if this medicine is recommended for certain conditions.

Possible Side Effects

• Bone pain
• Headache
• Nausea
• Fatigue
• Injection site reactions
• Splenic rupture
• Acute respiratory distress syndrome (ARDS)
• Sickle cell disease complications
• Capillary leak syndrome

Safety Advice

⚠️ Allergy

Get medical help right away if you have any very serious side effects, including rash, itching or swelling, severe dizziness, or trouble breathing. Please consult your healthcare provider.

🦴 Bone

Bone pain is a frequent side effect. It is usually treated with over-the-counter pain relievers such as acetaminophen or ibuprofen. Consult your healthcare provider before taking any medication.

🤰 Pregnancy

Pegstim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Please discuss this with your healthcare provider.

🤱 Breast Feeding

Breastfeeding women should talk to their healthcare provider before taking this medicine.

Storage Instructions

Refrigerate at 2°C to 8°C (36°F to 46°F). Do not freeze. Store in the original carton and protect from light. Do not shake the syringe.

References

• FDA (Amgen). NEULASTA (pegfilgrastim) Full Prescribing Information. 2025.
• StatPearls. Pegfilgrastim. Treasure Island (FL): StatPearls Publishing.
• Goodman & Gilman’s. The Pharmacological Basis of Therapeutics. 13th ed. New York: McGraw-Hill.
• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.
• Smith TJ, Bohlke K, Lyman GH, et al. Recommendations for the Use of WBC Growth Factors: ASCO Clinical Practice Guideline Update. J Clin Oncol. 2015;33(28):3199-3212.

Disclaimer

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