Soranib 200mg Tablet 30’s

Soranib 200mg Tablet contains Sorafenib which is a tyrosine kinase inhibitor used to treat cancers of liver, kidney and thyroid.

Uses of Soranib 200mg Tablet 30’s:

• Renal Cancer
• Liver Cancer
• Thyroid cancer

How does the Soraib 200mg Tablet 30’s work?

Sorafenib is a multi-kinase inhibitor that targets the receptor tyrosine kinases involved in tumor angiogenesis and tumor development. It prevents mostly:

• The receptor for vascular endothelial growth factor
• Platelet derived growth factor receptor
• A component of the MAPK/ERK signaling cascade is Raf kinase.

Sorafenib inhibits these pathways , which prevents tumor growth , reduces angiogenesis ( creation of new blood vessels ) , and causes cancer cells to undergo programmed cell death ( apoptosis ) .

How to Use & Dosage

The usual recommended dose of Soranib Tablet is 400 mg twice daily, with dose titration based on tolerance and clinical response. It should be taken on an empty stomach, at least 1 hour before or 2 hours after meals. The tablets should be swallowed whole with water without crushing or chewing.

If you are using it for children then consult your physician and follow the prescription. Take the medicine as directed regularly. If you suspect someone has taken an overdose, call emergency services or a poison control center immediately.

Possible Side Effects:

• Diarrhea
• Fatigue
• Nausea
• Vomiting
• Skin rash or dermatitis
• Hand-foot syndrome
• Hypertension
• Gastrointestinal bleeding
• Heart failure

Possible Side Effects:

Lungs

Soranib 200mg tablets should be used with caution in patients with certain lung conditions. Please consult your health care provider.

Liver

Care should be taken when using soranib tablets in patients with severe liver disease. Dosage of Soranib tablets may require modification. Please discuss with your health care provider.

Pregnancy

There is clear evidence that Soranib tablets are dangerous to the developing fetus when taken during pregnancy. Please consult your health care provider.

Breastfeeding

The use of Soranib Tablets during pregnancy is not recommended. There is evidence that medication can be harmful to the fetus. Discuss with your health care provider.

Alcohol

It is not known whether it is safe to drink alcohol while taking Soranib Tablets. Discuss it with your health care professional.

Storage Instructions:

Store the product at room temperature: recommended range 20°C to 25°C. Store in a dry environment and away from moisture. Store in original packaging. Keep away from direct sunlight. Keep away from children

References

Llovet JM, et al. Sorafenib in Advanced Hepatocellular Carcinoma. N Engl J Med. 2008;359(4):378-390.
Escudier B, et al. Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma. N Engl J Med. 2007;356(2):125-134.
Brose MS, et al. Sorafenib in Radioactive Iodine-Refractory, Locally Advanced or Metastatic Differentiated Thyroid Cancer: A Randomised, Double-Blind, Phase 3 Trial. Lancet. 2014;384(9940):319-328.
NEXAVAR (sorafenib) Prescribing Information, U.S. FDA (accessdata.fda.gov) — Indications section.

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