Tigetop 50mg Injection

Tigetop 50mg Injection is a medicine containing Tigecycline which is an antibiotic belonging to the group of medicines known as glycylcyclines. The broad-spectrum antibiotic tigecycline can be used to treat a variety of bacterial infections, including those resistant to other antibiotics.

Uses of Tigetop 50mg Injection:

• Complex infections of the skin and soft tissues
• Complicated intra-abdominal infections
• Community-acquired pneumonia

How does Tigetop 50mg Injection work?

Tigecycline binds to the 30S ribosomal subunit, preventing bacteria from synthesising proteins. This in effect halts the growth of bacteria by not allowing amino acids to be added to the growing peptide chain.

How to Use & Dosage

50 mg every 12 hours, usually administered intravenously over 30 to 60 minutes. Duration of treatment is determined on the type and severity of infection (usually 5 to 14 days).

Tigecycline injections can be given at home or in a hospital if a healthcare professional provides the correct instructions on how to administer the medication and deal with any problems.

You should start feeling better in the first few days of treatment with tigecycline injectable. If your symptoms do not improve or if symptoms worsen, contact your physician.

Possible Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Abdominal pain
• Elevated liver enzymes

Safety Advise:

🫀 Liver

Use caution when treating patients with liver dysfunction. Dose adjustment is necessary in severe liver dysfunction. Please talk to your healthcare provider.

🩺 Kidney

No dosage adjustment is required in patients with impaired renal function; however, patients with severe renal failure should be monitored with caution. Please speak to your healthcare provider.

🤰 Pregnancy

If a pregnant woman is given the drug, tigecycline may damage the fetus. Please consult your healthcare provider.

🤱 Breast Feeding

You should not use it while you are nursing, because it may pass into the breast milk and cause harm to the baby. You need to speak with your physician.

🚗 Driving

Vision problems or dizziness may occur with tigecycline. Patients should be cautioned against driving if these effects occur. Please consult your healthcare provider.

Storage Instructions:

Store at 25°C (77°F) with allowable temperature variations of 15°C to 30°C (59°F to 86°F). Store in the original container, protected from light.

References

1. TYGACIL® (tigecycline) for injection, for intravenous use. Full Prescribing Information. Pfizer Inc. Revised 2013. Silver Spring, MD: U.S. Food and Drug Administration.
2. U.S. Food and Drug Administration. FDA Drug Safety Communication: FDA Warns of Increased Risk of Death with IV Antibacterial Tygacil (Tigecycline) and Approves New Boxed Warning. FDA Drug Safety Communication. 2013.
3. Babinchak T, Ellis-Grosse E, Dartois N, Rose GM, Loh E. The Efficacy and Safety of Tigecycline for the Treatment of Complicated Intra-Abdominal Infections: Analysis of Pooled Clinical Trial Data. Clinical Infectious Diseases. 2005;41(Suppl 5):S354-S367.
4. Zhang Q, Zhou S, Zhou J. Dose Optimisation Based on Pharmacokinetic/Pharmacodynamic Target of Tigecycline. Journal of Global Antimicrobial Resistance. 2021;25:329-335.
5. Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.

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