Zemdri 500mg/10ml Injection

Zemdri 500mg/10ml Injection contains Plazomicin, a next-generation aminoglycoside antibiotic. It’s approved for the treatment of complicated urinary tract infections (cUTIs), which may include kidney infections caused by susceptible bacteria.

Uses of Zemdri 500mg/10ml Injection:

• Urinary Tract Infections

How does Zemdri 500mg/10ml Injection work?

Plazomicin acts by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit. The production of defective proteins in turn results in the death of bacterial cell. It is effective against multidrug resistant Gram-negative bacteria because it is designed to bypass many of the common aminoglycoside resistance mechanisms.

How to Use & Dosage

Zemdri is given intravenously. The recommended dose is the same as usual and is given over 30 minutes based on body weight (15 mg/kg once daily).

The drug is administered intravenously. Usually given by your care team in a hospital or clinic. It can also be administered at home.

You will be instructed on how to prepare and administer this medication if you receive it at home. Follow the instructions exactly. Take at the same time each day as directed on the prescription label. Continue to take it unless told otherwise by your healthcare team.

It is very important to always put used syringes and needles in a special container for sharps. Don’t let them go in the garbage can. If you don’t have a sharps container, call your chemist or care team for one.

Possible Side Effects:

• Diarrhea
• Nausea
• Vomiting
• Dizziness
• Headache
• Kidney function Changes
• Ototoxicity (Hearing Impairment)

Safety Advise:

🫁 Lungs

It is not known whether Zemdri Injection is safe in people with lung problems. Discuss with your health care provider.

🩸 Liver

It is not known whether Zemdri Injection is safe for use in patients with liver problems. Talk to your doctor.

🩺 Kidney

Safety of Zemdri Injection in kidney problems is not known. You should consult with your doctor.

🤰 Pregnancy

Zemdri should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

🤱 Breast Feeding

Breastfeeding is likely not safe during treatment with Zemdri. Consult your physician.

Storage Instructions:

Store at a controlled room temperature between 20° and 25°C. Keep out of the light, do not freeze.

References

1. Shaeer KM, Zmarlicka MT, Chahine EB, Piccicacco N, Cho JC. Plazomicin: a next‐generation aminoglycoside. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2019 Jan;39(1):77-93.
2. Saravolatz LD, Stein GE. Plazomicin: a new aminoglycoside. Clinical Infectious Diseases. 2020 Feb 3;70(4):704-9.
3. Galani I. Plazomicin: aminoglycoside antibiotic. Drugs Future. 2014;39(1):25-35.

Disclaimer:

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Manufacturer details

Name: Cipla Ltd.

Address: Cipla House, Peninsula Business Park, Lower Parel, Mumbai, Maharashtra – 400013, India

Country of origin: India