Coly-Monas 1 MIU Injection

Coly-Monas 1 MIU Injection contains Colistimethate Sodium, a polymyxin antibiotic that is used to treat serious infections caused by multidrug resistant Gram-negative bacteria. It is often reserved as a last resort when other antibiotics have not worked, typically in hospital.

Uses of Coly-Monas 1 MIU Injection:

• Severe Bacterial Infections

How does Coly-Monas 1 MIU Injection work?

Colistin sodium is an inactive prodrug that is converted by the body to its active form after administration. The bactericidal effect of colistin results from its interaction with phospholipids and lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria. This binding breaks down the cell membrane, making it permeable so cellular contents flow out, killing the bacteria cells.

How to Use & Dosage

Typically given as an IV infusion. The dose depends on the severity of the infection, the body weight of the patient and renal function. Healthcare practitioners must carefully monitor it to make adjustments based on toxicity risk and therapeutic response.

Colistimethate injections are usually given every 6 to 12 hours as a muscle injection or as a powder and liquid mixture that is injected into a vein over a period of 3 to 5 minutes. How long you need therapy depends on your health, the type of illness and how you respond to the drug. It can also be administered as a 22-23 hour continuous infusion.

Even if you feel better, continue to use the colistimethate injection until you have completed the prescription. If you stop the colistimethate injection too soon or miss doses, your infection may not be fully treated and the bacteria may become resistant to antibiotics.

Possible Side Effects:

• Dizziness
• Tingling
• Muscle weakness
• Nausea
• Vomiting
• Skin Rash
• Itching
• Diarrhea
• Kidney Damage

Safety Advise:

🫁 Lungs

It is not known whether Colymonas Injection is safe for people with lung problems. Discuss with your healthcare provider.

🟤 Liver

It is not known whether Colymonas Injection is safe to use in patients with liver problems. Please consult your health care provider.

🫘 Kidney

Colymonas Injection is not known to be safe for use in kidney patients. Talk with your health care provider.

🤰 Pregnancy

Colymonas during pregnancy should only be used when clearly needed. Please consult with your doctor.

🤱 Breastfeeding

It is very likely unsafe to use Colymonas while nursing. Discuss with your health care provider.

Storage Instructions:

Store the vial at 2°C to 8°C. Keep in the original packaging to protect it from light. Do not freeze.

References

Colistimethate for Injection, USP. Prescribing Information / Package Insert. U.S. Food and Drug Administration.

Yendewa GA, Griffiss JM, Gray WA, et al. Dosing Colistimethate Every 8 h Results in Higher Plasma Concentrations of Active Colistin Than Every 12-Hourly Dosing Without Increase in Nephrotoxicity: A Phase 1 Pharmacokinetics Trial in Healthy Adult Volunteers. Antibiotics. 2022;11(4):490.

Nation RL, Velkov T, Li J. Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese? Clinical Infectious Diseases. 2014;59(1):88-94.

Tsuji BT, Pogue JM, Zavascki AP, et al. International Consensus Guidelines for the Optimal Use of the Polymyxins. Pharmacotherapy. 2019;39(1):10-39.

Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.

Disclaimer:

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Manufacturer details

Name: Glenmark Pharmaceuticals Ltd

Address: Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.

Country of origin: India