Cabotres 40mg Tablet

Cabotres 40mg Tablet Composition: Cabozantinib. Cabotinib is a tyrosine kinase inhibitor (TKI) that inhibits multiple receptor tyrosine kinases (RTKs) involved in tumor growth, metastasis, and angiogenesis and is used for the treatment of several different cancers.

Uses of Cabotres 40mg Tablet

• Liver Cancer
• Kidney Cancer
• Medullary thyroid Cancer

How does Cabotres 40mg Tablet work?

Cabozantinib inhibits the activity of several tyrosine kinases, including MET, VEGFR and RET, which are involved in several pathways important for tumour cell development and angiogenesis (blood vessel formation). The drug cabozantinib blocks these kinases and may reduce blood flow to tumours as well as block the growth and spread of cancer cells.

How to Use & Dosage

The usual dose of Cabotres is 40-60 mg once daily depending on the type of cancer being treated and factors such as liver or renal function of the patient. Take on an empty stomach, at least two hours before or after a meal.

Cabozantinib is a pill that is usually taken once a day on an empty stomach (at least 1 hour before or 2 hours after a meal). Listen closely to what your doctor says and don’t change the dose without talking to your doctor.

Take the tablets whole with a full glass of water. Don’t open, crush, chew or split.

Possible Side Effects

• Diarrhea
• Fatigue
• Nausea
• Vomiting
• Anemia
• Decreased appetite
• Weight loss
• Elevated liver enzymes
• Hypertension (high blood pressure)
• Palmar-plantar erythrodysesthesia (hand-foot syndrome)

Safety Advise

🫘 Kidney

Dose adjustments may be necessary in patients with renal impairment and regular monitoring of renal function is advisable. Talk with your health care provider.

🫀 Liver

Dose adjustments may be necessary for patients with liver problems and regular monitoring of liver function is recommended. Please discuss with your healthcare provider.

🤰 Pregnancy

Cabozantinib is not recommended in pregnancy as it may cause harm to the foetus. Please ask your doctor.

🤱 Breastfeeding

Cabotres 40mg Tablet is likely unsafe to use during pregnancy. Please see your health care provider.

🍺 Alcohol

It is not known whether it is safe to consume alcohol with Cabotres 40mg Tablet. Discuss with your doctor.

Storage Instructions

Store between 15° and 30°C (59° and 86°F). Store in a dry place, away from direct light and moisture.

References

• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.
• Katzung BG, Vanderah TW. Basic and Clinical Pharmacology. 15th ed. New York: McGraw Hill.
• Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Molecular Cancer Therapeutics. 2011;10(12):2298-2308.
• Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. Journal of Clinical Oncology. 2013;31(29):3639-3646.
• Exelixis, Inc. Cabometyx (cabozantinib) Tablets Prescribing Information. Full Prescribing Information, U.S. Food and Drug Administration.

Disclaimer

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Frequently Asked Questions (FAQs)

What is Cabotres 40mg Tablet used for?

It is used to treat advanced renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer) and differentiated thyroid cancer.

How does Cabotres 40mg Tablet work?

It inhibits several tyrosine kinase receptors such as VEGFR and MET, decreasing the growth of the tumour and the formation of new blood vessels.

Is Cabotres a chemotherapy medicine?

No. It is a targeted therapy drug and belongs to the tyrosine kinase inhibitor (TKI) class of drugs.

What is Cabozantinib?

Cabozantinib is a targeted cancer drug that blocks proteins involved in tumour growth, angiogenesis and metastasis.

Does Cabotres cure Kidney Cancer?

Yes. It is used to treat advanced renal cell carcinoma (RCC).

Manufacturer Details

Name: Cipla Ltd

Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: India