Poly B 500000IU Injection

Poly B 500000 IU Injection contains Polymyxin B, an antibiotic used to treat serious bacterial infections caused by Gram-negative bacteria that are resistant to many drugs, is included in the injection. It kills cells by breaking the cell membrane of the bacteria.

Uses of Poly B 500000 IU Injection:

• Severe Bacterial Infections

How does the Poly B 500000 IU injection work?

Polymyxin B is a cationic polypeptide antibiotic that interacts with and disrupts the outer membrane of Gram-negative bacteria. This causes bacterial cell lysis and leakage of intracellular components and death eventually. Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacteriaceae are the multidrug-resistant Gram-negative bacteria to which it is mainly targeted.

How to Use & Dosage

Depending on the clinical situation, the administration route could be intramuscular (IM) or intravenous (IV). adjusted for severity of infection and weight. Renal impairment; dose adjustment may be required.

This medication is given by injection into a muscle, spinal fluid, or vein by a medical practitioner. It may also be given in the eye. Sometimes it is used with a solution of water to treat the skin. Follow the directions on the prescription label and the directions of your doctor or health care professional. Do not take your medication more often than prescribed.

Discuss the use of this medication in children with your pediatrician. You might have to be extra careful.

Possible Side Effects:

• Neurotoxicity
• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Neuromuscular blockade
• Respiratory failure
• Allergic reactions

Safety Advise:

🫁 Lungs

It is not known if Poly B is safe in people with lung problems. Talk with your health care provider.

🫀 Liver

The safety of Poly B for individuals with liver issues is uncertain. Please speak with your healthcare provider.

🩺 Kidney

Poly B safety for Kidney issues is unknown. Talk to your health care provider.

🤰 Pregnancy

Use only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

🤱 Breastfeeding

Probably dangerous to take Poly B while nursing. Make sure to talk to your healthcare provider.

Storage Instructions:

Store in a dry place below 25°C, away from direct sunlight.

References

1. Polymyxin B for Injection, USP. Prescribing Information / Package Insert. U.S. Food and Drug Administration.
2. Tsuji BT, Pogue JM, Zavascki AP, et al. International Consensus Guidelines for the Optimal Use of the Polymyxins. Pharmacotherapy. 2019;39(1):10-39.
3. Sandri AM, Landersdorfer CB, Jacob J, et al. Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens. Clinical Infectious Diseases. 2013;57(4):524-531.
4. Nation RL, Velkov T, Li J. Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese? Clinical Infectious Diseases. 2014;59(1):88-94.
5. Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.

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