Canrib 100mg Tablet

Canrib 100mg Tablet is a medicine that contains Olaparib. It is used to treat breast and ovarian cancer. It blocks the PARP enzyme which helps in repair of damaged DNA in cancer cells.

Uses of Canrib 100mg Tablet

• Breast Cancer
• Pancreatic Cancer
• Ovarian Cancer

How does Canrib 100mg work?

Olaparib works by inhibiting PARP enzymes which are involved in DNA repair processes. Olaparib works by blocking these enzymes so that cancer cells cannot repair their damaged DNA. This causes the cell to die, especially in those cells which do not already have DNA repair systems in place due to BRCA mutations.

How to Use & Dosage

Canrib is the oral form of administration with or without meals. Do not chew or crush the pills. Swallow them whole. The usual dose of Olaparib is 300 mg by mouth twice daily. The dose may change depending on the patient’s condition and treatment plan.

Drink this medicine with a full glass of water. Do not chew, crush or cut this medication. May be taken with or without food. If you feel nausea, take with food. However, avoid grapefruit juice, grapefruit, and Seville oranges while using this medication.

Stick to your medicine regularly. Do not use it more often than prescribed. Do not stop taking it except on advice of your physician. Talk to your doctor about the use of this medication in children. More care may be required.

If you think you have taken too much of this medicine, call your healthcare provider or local poison control center immediately.

Possible Side Effects

• Nausea
• Vomiting
• Fatigue
• Dizziness
• Fever
• Anemia (low red blood cell count)
• Neutropenia (low white blood cell count)
• Diarrhea

Safety Advise

🫁 Lungs

There is uncertainty about the safety of Canrib in people with lung problems. Please talk to your healthcare provider.

🫀 Liver

Canrib safety in people with liver problems is unknown. Please consult your health care provider.

🤰 Pregnancy

Canrib should be used during pregnancy only if clearly needed. Please consult your healthcare provider.

🤱 Breastfeeding

Canrib nursing warnings. Caution should be exercised if Canrib is used during breastfeeding. Talk to your healthcare provider.

Storage Instructions

Store in a dry place away from moisture. Store between 20°C and 25°C. Keep in original packaging and away from direct sunlight.

References

• Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.
• Katzung BG, Vanderah TW. Basic and Clinical Pharmacology. 15th ed. New York: McGraw Hill.
• Lord CJ, Ashworth A. PARP inhibitors: Synthetic lethality in the clinic. Science. 2017;355(6330):1152-1158.
• Moore K, Colombo N, Scambia G, et al. Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer. New England Journal of Medicine. 2018;379(26):2495-2505.
• AstraZeneca Pharmaceuticals LP. Lynparza (olaparib) Tablets Prescribing Information. Full Prescribing Information, U.S. Food and Drug Administration.

Disclaimer

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Frequently Asked Questions (FAQs)

What is Canrib 100mg Tablet used for?

It is used for ovarian cancer, breast cancer, pancreatic cancer and metastatic prostate cancer that is caused by a mutation in the BRCA gene.

How does a Canrib 100mg Tablet work?

It inhibits the PARP enzyme so that cancer cells cannot repair damaged DNA and thus the cancer cells die.

Is Canrib a chemotherapy medicine?

No. It is a targeted therapy drug of the class called PARP inhibitor.

What is a PARP inhibitor?

They target DNA repair enzymes known as PARP inhibitors and are particularly effective in cancers with mutations in the BRCA genes.

Is Canrib used in ovarian cancer?

Yes. It is commonly used as maintenance therapy following platinum-based chemotherapy in eligible patients with ovarian cancer.

Manufacturer Details

Name: Adley Formulations Pvt Ltd India

Address: Cabin No. 1, 1st Floor, SCO-184, Sector-5, Panchkula, Haryana, 134114, India

Country of origin: India