Dasanat 50mg Tablet

Dasanat 50 mg Tablet contains dasatinib. Active ingredient: dasatinib This is a type of cancer (chemotherapy) drug called a tyrosine kinase inhibitor. It is mainly used to treat Philadelphia chromosome-positive leukemias (Ph+ leukemias) such as Acute lymphoblastic leukemia and Chronic Myeloid leukemia.

Brand Name: Dasanat

Composition: Dasatinib

Mechanism of Action:

Dasatinib inhibits several tyrosine kinases which are essential for the growth and survival of cancer cells. It acts specifically on the BCR-Abl protein, generated in Acute lymphoblastic leukemia (ALL) and Chronic Myeloid leukemia (CML) as a consequence of the abnormal Philadelphia chromosome. This protein is blocked by dasatinib, which prevents cancer cells from growing and causes them to die.

Uses:

• Acute lymphoblastic leukemia (ALL)
• Chronic Myeloid leukemia (CML)

Dosage and how to take it:

The dose of Dasatinib is based on the condition being treated and how well the patient responds to treatment. Take tablets by mouth with or without food. Do not crush or break the tablets so that the drug is not absorbed through your skin.

Possible Side Effects:

• Fatigue
• Nausea
• Vomiting
• Diarrhea
• Skin rash
• Headache
• Muscle or joint pain
• Pulmonary Hypertension
• Anemia
• Fever
• Low blood platelets

Safety Advice

Liver

Temozolomide may cause damage to the liver. Routine liver function tests are needed to monitor your liver’s health during therapy. Consult with your health care provider.

Kidney

Renal injury may be caused by temozolomide. While you are on therapy, you will need to have regular kidney function tests to keep an eye on your kidney health. Please see your health care provider.

Pregnancy

Temozolomide can also cause birth defects. Females of childbearing potential should use effective contraception throughout the treatment period. Please consult your health care professional.

Breast-Feeding

You should not breast-feed while you are being treated. The drug may pass into the breast milk and could harm the baby. Please see your doctor.

Alcohol

Avoid alcohol while taking Temozolomide because it can increase side effects such as nausea, vomiting and liver damage. Please discuss with your health care provider.

Driving:

Temozolomide can cause fatigue, anxiety or dizziness. Do not drive a car if you have any of these side effects. Please discuss with your health care provider.

Storage:

Store at room temperature (15°C – 30°C), away from moisture and direct sunlight. Keep the medication out of reach of children.

How to use this Medication?

Take this medicine by mouth with water, following the prescription label, and avoid grapefruit juice. Do not cut or crush it, and avoid antacids or other acid-reducing medicines within 2 hours of taking this medication.

Consult your pediatrician about the usage of this medication in young patients. Although this medication may be administered for specific diseases in children as young as one year old, there are some things to keep in mind.

References:

1. Nuli MV, Rekulapally VK. Overall review on analytical method development and validation of Dasatinib. International Journal of Pharmacognosy and Chemistry. 2023 Mar 31:27-34.
2. Lindauer M, Hochhaus A. Dasatinib. Small Molecules in Oncology. 2014 Apr 23:27-65.
3. Kantarjian H, Jabbour E, Grimley J, Kirkpatrick P. Dasatinib. Nature reviews Drug discovery. 2006 Sep 1;5(9).
4. Aguilera DG, Tsimberidou AM. Dasatinib in chronic myeloid leukemia: a review. Therapeutics and Clinical Risk Management. 2009 May 4:281-9.

Disclaimer:

IHS Enterprises’s primary objective is to guarantee the accuracy, reliability, and specialist review of the information it provides to customers. The contents and information provided on this website are for informational purposes only. They should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician for guidance and any questions you may have about any condition or medication. If you do read anything from IHS Enterprises, please do not discount or delay in seeking competent medical advice. We want to enhance the doctor-patient relationship, not substitute it.

Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India