Viacease-B Injection

Viacease-B Injection is an antibiotic used to treat serious bacterial infections caused by drug-resistant Gram-negative bacteria. It contains Polymyxin B. It breaks the cell membrane of the bacteria and causes the cell to die.

Uses of Viacease-B Injection:

• Severe Bacterial Infections

How does Viacease-B Injection work?

Polymyxin B is a cationic polypeptide antibiotic that binds to and disrupts the outer membrane of Gram-negative bacteria. This causes lysis of bacterial cells, leakage of intracellular components and eventually death. It is mainly directed against multidrug-resistant Gram-negative bacteria, such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacteriaceae.

How to Use & Dosage

This drug is given by a health care professional as an injection into muscle, spinal fluid, or vein. It can also be administered in the eye. This medicine is sometimes used with an irrigation solution to treat the skin. Depending on the clinical scenario, adjusted for severity of infection and weight. Patients with renal impairment may require dose adjustments.

Follow the directions on the prescription label and your healthcare provider’s directions. Do not take your medication more often than prescribed. Discuss the use of this medication in children with the pediatrician. Extra care may be required.

Possible Side Effects:

• Neurotoxicity
• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Neuromuscular blockade
• Respiratory failure
• Allergic reactions

Safety Advise:

🫁 Lungs

It is unknown if it is safe to use Viacease B in people with lung problems. Please consult your healthcare provider.

🫀 Liver

It is not known if Viacease B is safe and effective in people with liver problems. Please talk with your health care provider.

🩺 Kidney

The safety of Viacease B for people with Kidney issues is not known. Please speak to your health care provider.

🤰 Pregnancy

Viacease B should only be used in pregnancy if clearly needed. Discuss the risks and benefits with your doctor.

🤱 Breastfeeding

Using Viacease B when breastfeeding is probably not safe. Please check with your health care professional.

Storage Instructions

Store out of direct sunlight in a dry place below 25°C.

References

1. Polymyxin B for Injection, USP. Prescribing Information / Package Insert. U.S. Food and Drug Administration.
2. Tsuji BT, Pogue JM, Zavascki AP, et al. International Consensus Guidelines for the Optimal Use of the Polymyxins. Pharmacotherapy. 2019;39(1):10-39.
3. Sandri AM, Landersdorfer CB, Jacob J, et al. Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens. Clinical Infectious Diseases. 2013;57(4):524-531.
4. Nation RL, Velkov T, Li J. Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese? Clinical Infectious Diseases. 2014;59(1):88-94.
5. Brunton LL, Knollmann BC, eds. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. New York: McGraw-Hill Education.

Disclaimer:

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Manufacturer details

Name: Mylan Pharmaceuticals Pvt Ltd – A Viatris Company

Address: Mylan Pharmaceuticals Private Limited, Commercial Operations, Prestige Tech Park, Platina-3, 7th to 12th floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103

Country of origin: India