Zoladex 10.8mg Injection

Zoladex 10.8mg Injection contains Goserelin acetate which is a synthetic hormone and a gonadotropin-releasing hormone (GnRH) analogue.

Uses Zoladex 10.8mg Injection :

• Prostate Cancer
• Breast Cancer
• Endometriosis
• Uterine Fibroids

How does Zoladex 10.8mg Injection work?

Zoladex works by preventing the pituitary gland from releasing gonadotropins (FSH and LH). This means that the body makes less of the sex hormones (oestrogen in women and testosterone in men) and so hormone levels fall.

How to Use & Dosage

Normally given as a subcutaneous injection monthly or every three months depending on the indication and treatment regimen. provided by a medical professional in a therapeutic setting.

This drug uses an implant to gradually release hormones into your body. The doctor gives you a shot, just under your belly button, under the skin of your lower abdomen. The implant itself will be completely absorbed by the body over a few weeks or months.

Take this medication as directed by your doctor. The 3.6 mg syringe is usually given every 4 weeks and the 10.8 mg syringe every 12 to 13 weeks. Follow your doctor’s instructions and put reminders on your calendar for when you need to take your doses. Don’t stop taking your medication without your doctor’s approval.

Possible Side Effects:

• Hot flashes
• Night sweat
• Weight gain
• Mood change
• Dizziness
• Allergic reactions
• Osteoporosis
• Reduced libido
• Nausea
• Vomiting
• Fever

Safety Advise:

🫁 Lungs

It is not known if Zoladex Injection is safe for people who have lung problems. Please speak with your health care provider.

🟤 Liver

We do not know if Zoladex Injection is safe for use in people with liver problems. Please discuss with your healthcare provider.

🫘 Kidney

The safety of Zoladex Injection in people with Kidney problems is unknown. Consult your health care provider

🤰 Pregnancy

Use Zoladex only if clearly needed during pregnancy, and talk to your healthcare provider.

🤱 Breastfeeding

It is likely that nursing will be unsafe when using Zoladex. Please contact your health care provider.

Storage Instructions:

Zoladex should be kept in the refrigerator (2°C to 8°C [36°F to 46°F]). Freezing may damage the formulation and should be avoided.

References

Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers.

Katzung BG, Vanderah TW. Basic and Clinical Pharmacology. 15th ed. New York: McGraw Hill.

Thompson IM. Flare Associated with LHRH-Agonist Therapy. Reviews in Urology. 2001;3(Suppl 3):S10-S14.

TerSera Therapeutics LLC. Zoladex (goserelin implant) 10.8 mg Prescribing Information. Full Prescribing Information, U.S. Food and Drug Administration.

Kumar D, Salian SR, Kalthur G, et al. Association between tumor flare and clinical outcomes in patients treated with GnRH agonists for prostate cancer. Reviews in Urology. 2013;15(1):8-15

Disclaimer:

IHS Enterprises’s primary objective is to guarantee the accuracy, reliability, and specialist review of the information it provides to customers. The contents and information provided on this website are for informational purposes only. They should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician for guidance and any questions you may have about any condition or medication. If you do read anything from IHS Enterprises, please do not discount or delay in seeking competent medical advice. We want to enhance the doctor-patient relationship, not substitute it.

Frequently Asked Questions (FAQs)

1. What is Zoladex 10.8mg Injection?

Zoladex 10.8mg contains the active ingredient Goserelin, which is an LHRH agonist. It is a hormone therapy that may be prescribed for the treatment of prostate cancer or certain gynaecological conditions. It is mandatory that a specialist’s protocol be strictly followed.

2. How does Zoladex work?

It is thought to initially overstimulate the body’s production of hormones, which could possibly lead to a subsequent long-term shutdown of testosterone production (in men) or oestrogen production (in women).

3. What are the conditions of it?

The 10.8mg long-acting dose is mainly considered for the treatment of advanced prostate cancer, upon the assessment of an oncologist or urologist.

4. How do I administer Zoladex 10.8mg?

It is given as a subcutaneous implant (injected under the skin of the abdomen) by a healthcare professional. You must follow the clinical administration schedule.

5. How often do I get the 10.8mg injection?

This specific depot formulation is usually administered once every 12 weeks (3 months). You must follow your doctor’s schedule to the letter and not miss appointments.

6. What are the potential side effects?

Patients may experience hot flushes, sweating, decreased libido, erectile dysfunction or pain at the injection site.

7. What is a ‘tumour flare’?

Hormone levels go up a little bit during the first few weeks and this could potentially make symptoms worse (bone pain, urinary problems). Follow your doctor’s recommendations for handling this early stage.

8. Will it impact bone density?

Suppressing hormones for a long time can thin the bones (osteoporosis). Your doctor will advise if you need to follow bone-protection therapies.

9. Are there any cardiovascular or metabolic risks?

Hormonal therapy may potentially increase risk for diabetes or cardiovascular disease. It’s essential to follow your doctor’s routine health screenings.

10. Is it possible to delay a dose?

A delay in the dose can allow the hormone levels to rise and possibly stimulate the growth of the cancer. “Medical professionals insist that the 12-week schedule be adhered to strictly.

11. How is it stored?

Usually It should be stored at room temperature (below 25 °C). If you are handling the package, follow your chemist’s instructions on how to store it.

12. Is Zoladex a prescription medication?

It’s a prescription-only drug and requires long-term medical adherence.

Medical Disclaimer

Zoladex 10.8mg Injection is a prescription medication and should only be used by the patient under the strict supervision and guidance of a qualified medical professional. Do not self-medicate, change the dose or stop using it without the advice of your doctor. The information contained herein is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis or treatment. Individual results, benefits and risks may vary. Always consult your physician before starting, stopping, or changing any medication.

Manufacturer details

Name: AstraZeneca

Address: Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore

Country of origin: India