Daslemia 100mg Tablet

Daslemia 100 Mg Tablet contains dasatinib which is a chemotherapy drug, a type of medicine called a tyrosine kinase inhibitor. It is primarily used to treat Philadelphia chromosome (Ph+) positive leukaemias, such as Acute lymphoblastic leukaemia and Chronic Myeloid leukaemia.

Brand Name: Daslemia

Composition: Dasatinib

Mechanism of Action:

Dasatinib works by blocking a number of tyrosine kinases that are important for cancer cells to grow and live. It specifically targets the BCR-ABL protein that is produced in Acute lymphoblastic leukaemia (ALL) and Chronic Myeloid leukaemia (CML) due to the abnormal Philadelphia chromosome. Dasatinib blocks this protein which stops the cancer cells from growing and causes them to die.

Uses:

• Acute lymphoblastic leukemia (ALL)
• Chronic Myeloid leukemia (CML)

Dosage and how to take it:

100 mg once daily as prescribed by your healthcare professional. Dosage depends on the condition being treated and the patient’s response to therapy. The tablet is taken by mouth with or without food . Swallow whole. Do not crush or chew.

Possible Side Effects:

• Fatigue
• Nausea
• Vomiting
• Diarrhea
• Skin rash
• Headache
• Muscle or joint pain
• Pulmonary Hypertension
• Anemia
• Fever
• Low blood platelets

Safety Advice

Liver

Temozolomide may cause damage to the liver. Routine liver function tests are needed to monitor your liver’s health during therapy. Consult with your health care provider.

Kidney

Renal injury may be caused by temozolomide. While you are on therapy, you will need to have regular kidney function tests to keep an eye on your kidney health. Please see your health care provider.

Pregnancy

Temozolomide can also cause birth defects. Females of childbearing potential should use effective contraception throughout the treatment period. Please consult your health care professional.

Breast-Feeding

You should not breast-feed while you are being treated. The drug may pass into the breast milk and could harm the baby. Please see your doctor.

Alcohol

Avoid alcohol while taking Temozolomide because it can increase side effects such as nausea, vomiting and liver damage. Please discuss with your health care provider.

Driving:

Temozolomide can cause fatigue, anxiety or dizziness. Do not drive a car if you have any of these side effects. Please discuss with your health care provider.

Storage:

Store at normal room temperature (15°C – 30°C) away from moisture and direct sunlight Keep out of reach of children.

How to use this Medication?

Take this medicine by mouth with water as directed on the prescription label. Do not take with grapefruit juice. Do not crush or split the tablet. Do not take antacids or other acid reducing medications for 2 hours after taking this medication.

Talk with the doctor before using this medicine in children. This medicine can be given to children as young as 1 year old for some diseases but there are some things to remember.

References:

1. Sankar PR, Sailu AB, Eswarudu MM, Satya MN, Sreeja P, Roja P, Rijwana S. Analytical methods for determination of different members of FDA approved tyrosine kinase inhibitors like Dasatinib, Lapatinib, Imatinib, Sorafenib, Nintedanib, Sunitinib and Pazopanib: a review. Journal of Pharmaceutical Sciences and Research. 2021 Jun 1;13(6):313-8.
2. Lindauer M, Hochhaus A. Dasatinib. Small Molecules in Oncology. 2014 Apr 23:27-65.
3. Kantarjian H, Jabbour E, Grimley J, Kirkpatrick P. Dasatinib. Nature reviews Drug discovery. 2006 Sep 1;5(9).
4. Aguilera DG, Tsimberidou AM. Dasatinib in chronic myeloid leukemia: a review. Therapeutics and Clinical Risk Management. 2009 May 4:281-9.

Disclaimer

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Marketer details

Name: Intas Pharmaceuticals Ltd

Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad – 380009. Gujarat. India.

Country of origin: India