Daslemia 50mg Tablet

Daslemia 50 mg Tablet contains the active ingredient dasatinib, a type of chemotherapy drug known as a tyrosine kinase inhibitor. It is mostly used to treat leukemias that are positive for the Philadelphia chromosome (Ph+), such as Acute lymphoblastic leukemia and Chronic Myeloid leukemia.

Uses of Daslemia 50mg Tablet:

• Acute lymphoblastic leukemia (ALL)
• Chronic Myeloid leukemia (CML)

How does Daslemia 50mg Tablet work?

Dasatinib works by inhibiting multiple tyrosine kinases that are essential for cancer cell growth and survival. It specifically targets the BCR-ABL protein which is produced in Acute lymphoblastic leukemia (ALL) and Chronic Myeloid leukemia (CML) due to the abnormal Philadelphia chromosome. Dasatinib blocks this protein to prevent cancer cells from growing and to cause them to die.

How to Use & Dosage

100 mg once daily or as directed by a healthcare provider. Dosage may vary depending on the condition being treated and the patient’s response to therapy. Take the tablet by mouth with food or on an empty stomach. It should be taken whole, not chewed or crushed.

Take this medicine by mouth with water, following the prescription label, and avoid grapefruit juice. Do not cut or crush it, and avoid antacids or other acid-reducing medicines within 2 hours of taking this medication. Consult your pediatrician about the usage of this medication in young patients. Although this medication may be administered for specific diseases in children as young as one year old, there are some things to keep in mind.

Possible Side Effects:

• Vomiting
• Diarrhea
• Skin rash
• Headache
• Muscle or joint pain
• Pulmonary Hypertension
• Anemia
• Fever
• Low blood platelets
• Nausea

Possible Side Effects:

Kidney

Kidney function tests should be conducted periodically, as dasatinib can cause renal toxicity. Kindly speak with your Healthcare Provider.

Liver

Liver function tests should be conducted periodically, as dasatinib can cause hepatic toxicity. Kindly speak with your Healthcare Provider.

Pregnancy

As dasatinib may harm the fetus, it is not advised to use it during pregnancy. During therapy, women who are or may get pregnant should take an effective form of contraception. Kindly speak with your Healthcare Provider.

Breast Feeding

It is not safe to use Daslemia 50mg Tablet during nursing. Evidence points to the possibility of medication poisoning in the fetus. Kindly speak with your Healthcare Provider.

Alcohol

It is unknown whether it is safe to take alcohol with Daslemia 50mg Tablet. Kindly speak with your Healthcare Provider.

Driving

Your ability to drive may be impacted by adverse effects from Daslemia 50mg Tablet. Kindly speak with your Healthcare Provider.

Storage Instructions

Store at room temperature (15°C – 30°C), away from moisture and direct sunlight. Keep the medication out of reach of children.

References:

1. Sankar PR, Sailu AB, Eswarudu MM, Satya MN, Sreeja P, Roja P, Rijwana S. Analytical methods for determination of different members of FDA approved tyrosine kinase inhibitors like Dasatinib, Lapatinib, Imatinib, Sorafenib, Nintedanib, Sunitinib and Pazopanib: a review. Journal of Pharmaceutical Sciences and Research. 2021 Jun 1;13(6):313-8.
2. Lindauer M, Hochhaus A. Dasatinib. Small Molecules in Oncology. 2014 Apr 23:27-65.
3. Kantarjian H, Jabbour E, Grimley J, Kirkpatrick P. Dasatinib. Nature reviews Drug discovery. 2006 Sep 1;5(9).
4. Aguilera DG, Tsimberidou AM. Dasatinib in chronic myeloid leukemia: a review. Therapeutics and Clinical Risk Management. 2009 May 4:281-9.

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